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Phosphatidylserine is the most abundant phospholipid in the human brain and is made by the body in small amounts. This important phospholipid supports neuronal cell integrity by providing the building blocks needed for cell membrane structure and function.^† Cell membranes not only act as a barrier between the inside and outside of a cell, but also play an important role in cellular communication and normal cellular responses. Phosphatidylserine has also been documented to increase the availability of choline for synthesis of acetylcholine, an important neurotransmitter involved in memory and learning. It may also help enhance cognitive function by maintaining cholinergic activity in the brain.^†

^{The brain makes up only 2% of a person’s body weight, yet it consumes roughly 20% of the body’s energy when at rest. Many nutrients have been shown to support optimal neurologic and cognitive function. In addition to the well-known omega-3 fatty acid DHA, other nutrients have demonstrated efficacy in supporting cognitive function.} 

Phosphatidylserine

Phosphatidylserine (PS) is an endogenous phospholipid. Although it is less abundant in the body than other phospholipids (i.e., phosphatidylcholine and phosphatidylethanolamine), it still comprises 2–10% of the body’s total phospholipids, with critical functions in several biological areas, such as apoptosis (programmed cell death), blood clotting, and cell-to-cell communication.¹ The PS molecule consists of a glycerol-phosphate backbone, the alpha-amino acid serine, and two fatty acids. As with other phospholipids, PS is a critical component in the structure of membranes, particularly neurons.²

In the body, phospholipids form a variety of structures owing to their amphipathic nature, i.e., having both a hydrophobic  (“water-fearing”) non-polar tail and hydrophilic (“water-loving’) polar head. They can move within the fluid mosaic of cell membranes, which supports cellular communication, selective passage of macromolecules, and other important cellular functions. Phosphatidylserine is the most abundant negatively charged phospholipid in eukaryotic cell membranes.³ As the major acidic phospholipid in the brain, PS can traverse the blood-brain barrier after oral administration.⁴ In animal studies, it has been shown to influence several neurochemical systems, neuronal membranes, cell metabolism, and several neurotransmitters, including serotonin and dopamine.^†5-7  

Several clinical trials have shown that PS supplementation supports cognitive function.^†

Several clinical trials have shown that PS supplementation supports cognitive function.^† In one randomized, controlled clinical trial, 36 children, aged 4 to 14 years, who were experiencing attention-related issues were given 200 mg/d of PS or placebo for two months.⁸ PS supplementation resulted in significant improvements in attention, impulsive movement, and short-term auditory memory as compared with placebo. PS was well-tolerated and showed no adverse effects. 

Phosphatidylserine has further been shown to support healthy endocrine and adrenal responses to mental stress.^†  In a double-blind study, PS (400 mg, 600 mg, or 800 mg/d) was administered to healthy women and men 20 to 45 years old.⁹ In the groups receiving 400 mg/d of PS only, researchers observed a pronounced blunting of both serum ACTH and cortisol, and salivary cortisol responses to the Trier Social Stress Test (TSST). There was also a positive effect on emotional responses to the TSST at 400 mg/d. While the placebo group showed the expected increase in distress after the test, the group treated with 400 mg PS showed a decrease. The effect was not seen with larger doses. These results suggest that PS may dampen hypothalamic-pituitary-adrenal (HPA) axis stress responses.^† 

Phosphatidylserine also supports cognitive function in aging individuals.^† In a clinical trial, 70 elderly subjects with cognition complaints were randomly allocated to four groups: 17 patients received only social support, 18 patients received cognitive training twice a week, 17 patients received cognitive training combined with pyritinol 2 x 600 mg/d, and 18 patients received cognitive training combined with phosphatidylserine (200 mg BID). Researchers concluded that PS supplementation combined with cognitive training led to transient improvement of cognitive and memory function, as well as improved electrophysiological brain function.^†10 

*Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Probiotic Complete is a robust, broad-spectrum, hypoallergenic blend of 12 probiotic species in a base of inulin. Designed to supply a complete component of synergistic and complementary species, each capsule provides 25 billion CFU protected by our proprietary InTactic® technology for maximum viability throughout the intestinal tract.

• Maximum probiotic support with colonizing and transient strains
• Clean and hypoallergenic for optimal results
• Available in 25B CFU capsules or 100B CFU powder

Probiotic Mechanisms

• Competitive and antagonistic activity against undesirable microorganisms*
• Strengthening of intestinal epithelial barrier integrity*
• Short chain fatty acid production nourishes enterocytes*
• Healthy inflammation balance*
• Support of innate and acquired immunity*

Should be refrigerated.

*Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Quercetin

• Potent bioflavonoid*
• Promotes healthy enzyme levels*
• Supports normal sinus and respiratory function*

Quercetin has been shown to be one of the most useful and physiologically active flavonoids.* Quercetin helps support stable mast cells to promote healthy inflammatory balance. This potent bioflavonoid can be used for maintaining or supporting the proper levels of enzymes and physiologic factors necessary for normal respiratory and sinus health, to help support seasonal respiratory challenges.*

*Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Want an autographed copy of The Iron Curse? This is only for people in the U.S. If you live outside the U.S, then paperback and E book must be ordered through amazon, and will not be autographed. Books will ship in November 2023. E books are available to purchase now.

About The Iron Curse:

What do joint pain, liver damage, fatigue, diabetes, mental illness, cancer, memory loss, Parkinson's, infertility, infections, digestive problems, vision loss, and even cardiovascular disease have in common? They could all be a result of undiagnosed and untreated high iron.

High iron can lead to a disease called hemochromatosis, which is the most common and easiest-to-treat disease, that you have never heard of. A silent epidemic of undiagnosed and untreated high iron is quietly destroying the health of millions of people. This is a curse that must be broken, which is what The Iron Curse sets out to accomplish.

Hemochromatosis is easy and inexpensive to screen for, diagnose, and treat; yet most people with this disease go undiagnosed and untreated. Chasing symptoms, and dancing around the diagnosis, is the status quo for people with hemochromatosis.

The Iron Curse explains what high iron does to the body and why. It also explains how to diagnose hemochromatosis, and other iron disorders, such as anemias, using simple labs and genetic testing. There is a section on Iron Curse Protocols, which explains natural ways to lower iron and support health and healing.

This book isn’t just about hemochromatosis, but also includes critical information about anemias, including iron-deficient anemia. The Iron Curse has depth and insight not found elsewhere.

After writing her first book, Genetic Testing: Defining Your Path to a Personalized Health Plan, Dr. Sutton diagnosed her husband with hereditary hemochromatosis, and high cortisol caused by a pituitary tumor, which she believes high iron contributed to. Since then, she has routinely diagnosed patients with both hereditary and non- hereditary hemochromatosis. She has seen how hemochromatosis can destroy one’s health, and how medical myths are contributing to its misdiagnosis. Dr. Sutton has created a plethora of unique and valuable educational resources including video workshops, genetic reports, and books. These resources and more information may be found at www.drchristysutton.com

Watch The Iron Curse Video Workshop at ironcurse.com

Want the cliff-notes version? See end of chapter summaries.

Vision Complete provides excellent support for those who want to maintain eye health and also for those seeking macular support as they age.*

• Provides Key Antioxidant Support for Eyes*
• Supports Macular Health*
• Helps Protects Macula Against Light Damage*
• Supports Ocular Circulation*

In the US, eye health is a major concern for those over 60 years of age. The eye is the most susceptible organ to oxidative damage caused by light, toxins (smoke), atmospheric oxygen and abrasion. As ultraviolet and blue light pass through the retina to the photoreceptors (rods and cones) and the pigmented epithelial (PE) cells, reactive oxygen species (free radicals) are generated. If there are insufficient antioxidants available to neutralize free radicals, the eye undergoes excessive oxidative damage.

Age Related Macular Degeneration (ARMD) is the number one cause of blindness in America. ARMD Eye Compelete  was formulated with a specific blend of botanicals, nutrients, antioxidants and minerals, shown in research to support healthy eye function. The formula provides antioxidant support as well as key nutrients to care for and maintain the long-term health of the eyes. 

Suggested Use: 2 capsules per day or as recommended by your health care professional.

*Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Clinical Applications
» Offers Antioxidant Protection for Cell Membranes and Lipids*
» Supports Healthy Cytokine and Eicosanoid Balance*
» Supports Neuroprotection and Cognitive Health*
» Supports Cardiovascular, Nervous, and Reproductive Systems*
» Supports Liver Health*
» Provides Mixed Tocopherols and Tocotrienols for Comprehensive Vitamin E Nutrition*

Vitamin E, in its natural form, comprises eight different compounds:
alpha-, beta-, gamma-, and delta-tocopherols and alpha-, beta-,
gamma-, and delta-tocotrienols. Both tocopherols and tocotrienols
are important to human health. Known as the “master antioxidant,”
vitamin E has the ability to attenuate oxidative stress, and its
antioxidant-related effects on various organs and systems have
been the focus of vast research. More recently, non-antioxidant

mechanisms have been proposed, such as those that affect cell-
signal transduction and gene expression.[1] Though the vast majority

of research has been on alpha-tocopherol, recent mechanistic studies

indicate that other isomers of vitamin E, such as gamma- and delta-
tocopherols and tocotrienols, have superior antioxidant and cell-
signaling properties that offer greater health benefits.*[2,3]

 *Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

1. Azzi A, Meydani SN, Meydani M, et al. The rise, the fall and the renaissance of vitamin E. Arch Biochem Biophys. 2016 Apr 1;595:100-08. [PMID: 27095224]
2. Jiang Q, Yin X, Lill MA, et al. Long-chain carboxychromanols, metabolites of vitamin
E, are potent inhibitors of cyclooxygenases. Proc Natl Acad Sci U S A. 2008 Dec
23;105(51):20464-69. [PMID: 19074288]
3. Ahsan H, Ahad A, Iqbal J, et al. Pharmacological potential of tocotrienols: a review. Nutr Metab (Lond). 2014 Nov 12;11(1):52. [PMID: 25435896]