Brain & Stress

Epigenozyme AgiNos formula is based on the latest Nobel Prize-winning research on nitric oxide, a naturally occurring compound in the body. Nitric oxide is an important messenger that signals a variety of responses at the cellular level which are beneficial to circulatory, immune, and nervous system functions. Epigenozyme's AngiNOS is a refreshing, effervescent powder that offers therapeutic levels of L-arginine and L-citrulline, two amino acids the body uses to make nitric oxide.*

*Statments regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Epigenozyme Inflam-Redux Teremero features BCM-95®—a 100% pure turmeric extract standardized to curcumin, demethoxycurcumin, bisdemethoxycurcumin, and essential oils of turmeric rhizome. This natural composition optimizes bioavailability and reflects true turmeric identity to deliver optimal health benefits. BCM-95 has been extensively studied and shows broad efficacy without the use of phospholipids, excipients, additives, carriers, nanotechnology, or bioenhancers.*

*Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or heath condition.

Epigenozyme Glucoraphanin Phase II Detox converts sulforaphane (SFN), which supports long-lasting antioxidant activity and detoxification . Supports the immune, nervous, and cardiovascular systems, addressing the maintenance of good health*. Glucoraphanin Phase II Detox provides 100 mg of glucoraphanin per capsule.* Provides Concentrated Glucoraphanin from Broccoli Seed Extract Supports Healthy Cell-Life Cycles.* Supports Phase II Detoxification Enzymes*

*Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

B vitamins are essential nutrients required for optimal health and functioning of numerous systems and biochemical reactions in the body, including energy production, brain, liver and nerve cell function, and muscle tone in the GI tract.^† Activated forms of folate (Metafolin^®‡ L-5-methyltetrahydrofolate) and vitamin B₁₂ (methylcobalamin) are used for enhanced absorption and bioavailability. This high-potency B-complex vitamin supplement is formulated to be hypoallergenic and yeast free.

*Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Epigenozyme High Poten-C is a blend of vitamin C and various flavonoid compounds to provide enhanced vitamin C support. Epigenozyme High Poten-C helps maintain a healthy immune system as well as support to blood vessel integrity and healthy cell function.

* High Poten-C contains 1730 mg per serving, which is significantly more than most vitamin C products*

*Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any diseases or health condition.

Melatonin Slow Release 2 mg tablet

Melatonin Slow Release contains 2 mg of high purity melatonin in a prolonged-release tablet, formulated to slowly breakdown and release in the small intestine.

Melatonin is primarily associated with supporting the body’s natural sleep cycle, however recent scientific advances suggest that it may play a role in cellular health. More than a dozen preliminary clinical trials have examined the role of melatonin in supporting healthy cells and tissues, promoting immune cell activity, and scavenging free radicals. Randomized studies have revealed the potential for melatonin to positively support heart, brain, retina, colon, breast, prostate, and lung tissues.*

• Supports cellular health*
• Promotes immune cell activity*
• Made with hypoallergenic, vegan ingredients

*Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Probiotic Complete is a robust, broad-spectrum, hypoallergenic blend of 12 probiotic species in a base of inulin. Designed to supply a complete component of synergistic and complementary species, each capsule provides 25 billion CFU protected by our proprietary InTactic® technology for maximum viability throughout the intestinal tract.

• Maximum probiotic support with colonizing and transient strains
• Clean and hypoallergenic for optimal results
• Available in 25B CFU capsules or 100B CFU powder

Probiotic Mechanisms

• Competitive and antagonistic activity against undesirable microorganisms*
• Strengthening of intestinal epithelial barrier integrity*
• Short chain fatty acid production nourishes enterocytes*
• Healthy inflammation balance*
• Support of innate and acquired immunity*

Should be refrigerated.

*Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Epigenozyme High Potency Omega-3 Fish Oil contains natural enzymatically enhanced monoglyceride fish oil that has a three times greater EPA/DHA absorption rate than an equivalent dose of ethyl ester fish oil*. Formulated to minimize digestive discomfort and decrease risk of burping up fish taste*. Support cardiovascular health*. Support anti-inflammation*. Support cognitive, brain, and eye health*.

*Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Quercetin

• Potent bioflavonoid*
• Promotes healthy enzyme levels*
• Supports normal sinus and respiratory function*

Quercetin has been shown to be one of the most useful and physiologically active flavonoids.* Quercetin helps support stable mast cells to promote healthy inflammatory balance. This potent bioflavonoid can be used for maintaining or supporting the proper levels of enzymes and physiologic factors necessary for normal respiratory and sinus health, to help support seasonal respiratory challenges.*

*Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Phosphatidylserine is the most abundant phospholipid in the human brain and is made by the body in small amounts. This important phospholipid supports neuronal cell integrity by providing the building blocks needed for cell membrane structure and function.^† Cell membranes not only act as a barrier between the inside and outside of a cell, but also play an important role in cellular communication and normal cellular responses. Phosphatidylserine has also been documented to increase the availability of choline for synthesis of acetylcholine, an important neurotransmitter involved in memory and learning. It may also help enhance cognitive function by maintaining cholinergic activity in the brain.^†

^{The brain makes up only 2% of a person’s body weight, yet it consumes roughly 20% of the body’s energy when at rest. Many nutrients have been shown to support optimal neurologic and cognitive function. In addition to the well-known omega-3 fatty acid DHA, other nutrients have demonstrated efficacy in supporting cognitive function.} 

Phosphatidylserine

Phosphatidylserine (PS) is an endogenous phospholipid. Although it is less abundant in the body than other phospholipids (i.e., phosphatidylcholine and phosphatidylethanolamine), it still comprises 2–10% of the body’s total phospholipids, with critical functions in several biological areas, such as apoptosis (programmed cell death), blood clotting, and cell-to-cell communication.¹ The PS molecule consists of a glycerol-phosphate backbone, the alpha-amino acid serine, and two fatty acids. As with other phospholipids, PS is a critical component in the structure of membranes, particularly neurons.²

In the body, phospholipids form a variety of structures owing to their amphipathic nature, i.e., having both a hydrophobic  (“water-fearing”) non-polar tail and hydrophilic (“water-loving’) polar head. They can move within the fluid mosaic of cell membranes, which supports cellular communication, selective passage of macromolecules, and other important cellular functions. Phosphatidylserine is the most abundant negatively charged phospholipid in eukaryotic cell membranes.³ As the major acidic phospholipid in the brain, PS can traverse the blood-brain barrier after oral administration.⁴ In animal studies, it has been shown to influence several neurochemical systems, neuronal membranes, cell metabolism, and several neurotransmitters, including serotonin and dopamine.^†5-7  

Several clinical trials have shown that PS supplementation supports cognitive function.^†

Several clinical trials have shown that PS supplementation supports cognitive function.^† In one randomized, controlled clinical trial, 36 children, aged 4 to 14 years, who were experiencing attention-related issues were given 200 mg/d of PS or placebo for two months.⁸ PS supplementation resulted in significant improvements in attention, impulsive movement, and short-term auditory memory as compared with placebo. PS was well-tolerated and showed no adverse effects. 

Phosphatidylserine has further been shown to support healthy endocrine and adrenal responses to mental stress.^†  In a double-blind study, PS (400 mg, 600 mg, or 800 mg/d) was administered to healthy women and men 20 to 45 years old.⁹ In the groups receiving 400 mg/d of PS only, researchers observed a pronounced blunting of both serum ACTH and cortisol, and salivary cortisol responses to the Trier Social Stress Test (TSST). There was also a positive effect on emotional responses to the TSST at 400 mg/d. While the placebo group showed the expected increase in distress after the test, the group treated with 400 mg PS showed a decrease. The effect was not seen with larger doses. These results suggest that PS may dampen hypothalamic-pituitary-adrenal (HPA) axis stress responses.^† 

Phosphatidylserine also supports cognitive function in aging individuals.^† In a clinical trial, 70 elderly subjects with cognition complaints were randomly allocated to four groups: 17 patients received only social support, 18 patients received cognitive training twice a week, 17 patients received cognitive training combined with pyritinol 2 x 600 mg/d, and 18 patients received cognitive training combined with phosphatidylserine (200 mg BID). Researchers concluded that PS supplementation combined with cognitive training led to transient improvement of cognitive and memory function, as well as improved electrophysiological brain function.^†10 

*Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Alpha-lipoic acid is an antioxidant made by the body. It is found in every cell, where it helps turn glucose into energy. Antioxidants attack "free radicals," waste products created when the body turns food into energy.

Clinical Applications